Ammonia → 1-(Phenylmethyl)-4-[3-(trifluoromethyl)phenyl]-4-piperidinemethanamine
Reaction equation
Cl.[CH2:2]([N:9]1[CH2:14][CH2:13][C:12]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[CH:18]=2)([C:15]#[N:16])[CH2:11][CH2:10]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.N>CO.[Ni]>[CH2:2]([N:9]1[CH2:14][CH2:13][C:12]([CH2:15][NH2:16])([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:24])[F:25])[CH:18]=2)[CH2:11][CH2:10]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
A mixture of 1.5 g of the compound obtained in step C of Preparation 1.4, 0.15 g of Raney® nickel and 5 ml of ammonia in 20 ml of MeOH is hydrogenated overnight at AT and under atmospheric pressure. The catalyst is filtered off and the filtrate is concentrated under vacuum. This gives 1.45 g of the expected product.