3-Chloropyridine-2-carboxylic acid → HCID 178522734, compound

HRID 1995355

Reaction equation

HRID 1995355 reaction equation
[Cl:1][C:2]1[C:3]([C:8]([OH:10])=O)=[N:4][CH:5]=[CH:6][CH:7]=1.[NH2:11][C:12]1[NH:16][N:15]=[N:14][N:13]=1>S(Cl)(Cl)=O>[NH:13]1[C:12]([NH:11][C:8]([C:3]2[C:2]([Cl:1])=[CH:7][CH:6]=[CH:5][N:4]=2)=[O:10])=[N:16][N:15]=[N:14]1

Participants

4

Reactant 2

HCID 8246323-Chloropyridine-2-carboxylic acidHCID 178509299HCID 178509299, compound

Product 1

HCID 178522734HCID 178522734, compoundYield 39.3%

Reagents, catalysts & solvents 1

HCID 24386Thionyl ChlorideSolvent

Procedure

0.53 g of 3-chloro-2-pyridinecarboxylic acid, 10 ml of thionyl chloride and 0.27 g of 5-aminotetrazole are treated in the same manner as described in Example 1. The crude product thus obtained is recrystallized from a mixture of dimethylformamide and ethanol, whereby 0.28 g of N-(5-tetrazolyl)-3-chloro-2-pyridinecarboxamide is obtained.

Workup

  1. customThe crude product thus obtained
  2. customis recrystallized from a mixture of dimethylformamide and ethanol

Sources & evidence

ORD record
ord-506cde04188f4f70be64ab4491622625
Source dataset
uspto-grants-1983_09
Patent number
US04404214

Linked notes

Loading…