4-Nitropicolinic Acid → HCID 178522692, compound

Reaction equation

[N+:1]([C:4]1[CH:9]=[CH:8][N:7]=[C:6]([C:10]([OH:12])=O)[CH:5]=1)([O-:3])=[O:2].[NH2:13][C:14]1[NH:18][N:17]=[N:16][N:15]=1>>[NH:15]1[C:14]([NH:13][C:10]([C:6]2[CH:5]=[C:4]([N+:1]([O-:3])=[O:2])[CH:9]=[CH:8][N:7]=2)=[O:12])=[N:18][N:17]=[N:16]1

Participants

Reactant 2

HCID 27628254-Nitropicolinic Acid

HCID 178509299HCID 178509299, compound

Product 1

HCID 178522692HCID 178522692, compoundYield 56.6%

Procedure

0.48 g of 4-nitro-2-pyridinecarboxylic acid, 0.48 g of N,N'-carbonyldiimidazole and 0.27 g of 5-aminotetrazole are treated in the same manner as described in Example 2. The crude product thus obtained is recrystallized from ethanol, whereby 0.38 g of N-(5-tetrazolyl)-4-nitro-2-pyridinecarboxamide is obtained.

Workup

customThe crude product thus obtained
customis recrystallized from ethanol

Sources & evidence

ORD record: ord-6a5b43bc75b34aa2a36e1cb16b496d27
Source dataset: uspto-grants-1983_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04404214

Reaction notes

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