Benzoic acid, 2-chloro-6-nitro-, methyl ester → Methyl 2-amino-6-chlorobenzoate
Reaction equation
[Cl:1][C:2]1[C:7]([C:8]([O:10][CH3:11])=[O:9])=[C:6]([N+:12]([O-])=O)[CH:5]=[CH:4][CH:3]=1.[H][H]>[Ni].CO>[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]([NH2:12])[C:7]=1[C:8]([O:10][CH3:11])=[O:9]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
4.5 gm (0.212 mol) of methyl 6-chloro-2-nitro-benzoate were hydrogenated with Raney nickel in 1.8 liters of methanol until the calculated amount of hydrogen was absorbed. The filtered reaction mixture was evaporated in vacuo, and the residue was distilled in vacuo.
Workup
- customwas absorbed
- customThe filtered reaction mixture
- customwas evaporated in vacuo
- distillationthe residue was distilled in vacuo
Sources & evidence
- ORD record
- ord-ff8c8899ad384fc487339258c97eb69f
- Source dataset
- uspto-grants-1983_09
- Patent number
- US04404230
Reaction notes
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