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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2000284Generated: October 25, 2026

Benzylamine → tert-butyl (3R,4R)-4-(benzylamino)-3-hydroxypiperidine-1-carboxylate

https://huagongshe.com/reaction/2000284

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzylamineHCID 7504—
Reactanttert-butyl (1S,6R)-7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylateHCID 55273474—
Reagent(3R,4R,5R,6R)-5-acetamido-2-[[(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-3-fluoro-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acidHCID 448383—
SolventDichloromethaneHCID 6344—
Producttert-butyl (3R,4R)-4-(benzylamino)-3-hydroxypiperidine-1-carboxylateHCID 67335553—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature80 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-1c3040b76b504d86bd8c0a07cbdfbbb6
Source note39k HTE dataset from Pfizer