1,3-Dipropylxanthine → Diethyl [3-(1,3-dipropylxanthin-7-yl)propyl]phosphonate

HRID 2001

Reaction equation

HRID 2001 reaction equation
[CH2:1]([N:4]1[C:13](=[O:14])[C:12]2[NH:11][CH:10]=[N:9][C:8]=2[N:7]([CH2:15][CH2:16][CH3:17])[C:5]1=[O:6])[CH2:2][CH3:3].Br[CH2:19][CH2:20][CH2:21][P:22]([O:27][CH2:28][CH3:29])(=[O:26])[O:23][CH2:24][CH3:25]>>[CH2:1]([N:4]1[C:13](=[O:14])[C:12]2[N:11]([CH2:19][CH2:20][CH2:21][P:22](=[O:26])([O:27][CH2:28][CH3:29])[O:23][CH2:24][CH3:25])[CH:10]=[N:9][C:8]=2[N:7]([CH2:15][CH2:16][CH3:17])[C:5]1=[O:6])[CH2:2][CH3:3]

Participants

3

Reactant 2

HCID 1693171,3-DipropylxanthineHCID 283500Diethyl (3-bromopropyl)phosphonate

Product 1

HCID 22446304Diethyl [3-(1,3-dipropylxanthin-7-yl)propyl]phosphonate

Procedure

The title substance was prepared from 1,3-dipropylxanthine and diethyl 3-bromopropanephosphonate analogously to Example 1 and chromatographed on silica gel (eluent: ethyl acetate/methanol 20:1).

Workup

  1. customchromatographed on silica gel (eluent: ethyl acetate/methanol 20:1)

Sources & evidence

ORD record
ord-37d510efe3de46df8fb8264294561f22
Source dataset
uspto-grants-1998_03
Patent number
US05728686

Linked notes

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