HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2016Generated: October 24, 2026
Potassium Carbonate → Diethyl [4-(7-benzyl-3-methylxanthin-1-yl)butyl]phosphonate
https://huagongshe.com/en/reaction/2016
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 7-Benzyl-3-methylxanthine | HCID 685630 | — |
| Reactant | Diethyl(4-chlorobutyl)phosphonate | HCID 19689195 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Diethyl [4-(7-benzyl-3-methylxanthin-1-yl)butyl]phosphonate | HCID 22446297 | — |
Reaction Steps
20.4 g (0.08 mol) of 7-benzyl-3-methylxanthine were suspended in 200 ml of dimethylformamide (DMF), treated with 22 g (0.96 mol) of diethyl 4-chlorobutanephosphonate and 13.8 g (0.1 mol) of activated potassium carbonate and heated at 70° C. for 4 hours and filtered, the filtrate was concentrated under reduced pressure and the oily residue which remained was taken up in ethyl acetate, filtered again and crystallized from diisopropyl ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05728686 |
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| Source dataset | uspto-grants-1998_03 |
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| ORD ID | ord-7a6debe642dd4a55a17f79ac83e9ef86 |
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| Source note | uspto-grants-1998_03 |
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