Diethyl (3-bromopropyl)phosphonate → Diethyl [3-(7-ethoxymethyl-3-methylxanthin-1-yl)propyl]phosphonate

HRID 2028

Reaction equation

HRID 2028 reaction equation
[CH2:1]([O:3][CH2:4][N:5]1[C:13]2[C:12](=[O:14])[NH:11][C:10](=[O:15])[N:9]([CH3:16])[C:8]=2[N:7]=[CH:6]1)[CH3:2].Br[CH2:18][CH2:19][CH2:20][P:21]([O:26][CH2:27][CH3:28])(=[O:25])[O:22][CH2:23][CH3:24]>>[CH2:1]([O:3][CH2:4][N:5]1[C:13]2[C:12](=[O:14])[N:11]([CH2:18][CH2:19][CH2:20][P:21](=[O:25])([O:26][CH2:27][CH3:28])[O:22][CH2:23][CH3:24])[C:10](=[O:15])[N:9]([CH3:16])[C:8]=2[N:7]=[CH:6]1)[CH3:2]

Participants

3

Reactant 2

HCID 283500Diethyl (3-bromopropyl)phosphonateHCID 137476847-Ethoxymethyl-3-methylxanthine

Product 1

HCID 22446302Diethyl [3-(7-ethoxymethyl-3-methylxanthin-1-yl)propyl]phosphonate

Procedure

The title substance was prepared from 0.048 mol of 7-ethoxymethyl-3-methylxanthine and 0.058 mol of diethyl 3-bromopropanephosphonate analogously to Example 32 and chromatographed on silica gel (eluent: ethyl acetate/methanol 10:1).

Workup

  1. customchromatographed on silica gel (eluent: ethyl acetate/methanol 10:1)

Sources & evidence

ORD record
ord-26849af8cbc844578b2946656b10208a
Source dataset
uspto-grants-1998_03
Patent number
US05728686

Linked notes

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