Acetone → 4-Tert-butyl-2-(2-formyl-4-methoxyphenoxymethyl)thiazole

Reaction equation

[Br:1][CH2:2][c:3]1[s:4][cH:5][c:6]([C:8]([CH3:9])([CH3:10])[CH3:11])[n:7]1.[C:23](=[O:24])([O-:25])[O-:26].[CH3:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34].[CH3:35][C:36](=[O:37])[CH3:38].[K+:27].[K+:28].[OH:12][c:13]1[c:14]([CH:15]=[O:16])[cH:17][c:18]([O:21][CH3:22])[cH:19][cH:20]1>>[CH2:2]([c:3]1[s:4][cH:5][c:6]([C:8]([CH3:9])([CH3:10])[CH3:11])[n:7]1)[O:12][c:13]1[c:14]([CH:15]=[O:16])[cH:17][c:18]([O:21][CH3:22])[cH:19][cH:20]1

Participants

Reactant 6

HCID 180Acetone

HCID 813Potassium Cation2×

HCID 8058Hexane

HCID 19660Carbonate Ion

HCID 956952-Hydroxy-5-methoxybenzaldehyde

HCID 196037502-Bromomethyl-4-tert-butylthiazole

Product 1

HCID 190928224-Tert-butyl-2-(2-formyl-4-methoxyphenoxymethyl)thiazole

Sources & evidence

ORD record: ord-8ec0c22f47b946578b8db76bf1ae0fdc
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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