1-Bromopropane → Diethyl [4-(3-ethyl-7-propylxanthin-1-yl)butyl]phosphonate
Reaction equation
[CH2:1]([N:3]1[C:11]2[N:10]=[CH:9][NH:8][C:7]=2[C:6](=[O:12])[N:5]([CH2:13][CH2:14][CH2:15][CH2:16][P:17](=[O:24])([O:21][CH2:22][CH3:23])[O:18][CH2:19][CH3:20])[C:4]1=[O:25])[CH3:2].Br[CH2:27][CH2:28][CH3:29]>>[CH2:1]([N:3]1[C:11]2[N:10]=[CH:9][N:8]([CH2:27][CH2:28][CH3:29])[C:7]=2[C:6](=[O:12])[N:5]([CH2:13][CH2:14][CH2:15][CH2:16][P:17](=[O:24])([O:18][CH2:19][CH3:20])[O:21][CH2:22][CH3:23])[C:4]1=[O:25])[CH3:2]Participants
3
Procedure
The title substance was prepared from 8.2 mmol of diethyl [4-(3-ethyl-xanthin-1-yl)butyl]phosphonate and 9.8 mmol of bromopropane analogously to Example 30 and chromatographed on silica gel (eluent: dichloromethane/methanol 20:1).
Workup
- customchromatographed on silica gel (eluent: dichloromethane/methanol 20:1)
Sources & evidence
- ORD record
- ord-6f7760bc41454f178cfc2b916e1815a1