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8-Chloro-7-fluoro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine → 8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine

HRID 2035426
Notes
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Reaction equation

HRID 2035426 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]2[CH2:11][CH2:10][NH:9][CH2:8][CH:7]([CH3:12])[C:6]=2[CH:13]=1.IC1C=CC2CCNCC(C)C=2C=1.FC(F)(F)C1C=CC2CCNCC(C)C=2C=1.FC(F)(F)C1C=CC2CCNCC(CC)C=2C=1.[Cl:60]C1C=CC2CCNCC(CC)C=2C=1.BrC1C=CC2CCNCC(CC)C=2C=1.IC1C=CC2CCNCC(CC)C=2C=1.ClC1C(Cl)=CC2C(C)CNCCC=2C=1.ClC1C(Cl)=CC2C(CC)CNCCC=2C=1.ClC1C(F)=CC2CCNCC(C)C=2C=1.ClC1C(F)=CC2CCNCC(CC)C=2C=1>>[Cl:60][C:2]1[CH:3]=[CH:4][C:5]2[CH2:11][CH2:10][NH:9][CH2:8][CH:7]([CH3:12])[C:6]=2[CH:13]=1
ParticipantsProcedureSources & evidenceReaction notes

Participants

12

Reactant 11

HCID 99908088-Chloro-7-fluoro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepineHCID 99914447,8-Dichloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepineHCID 100824778-Chloro-7-fluoro-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepineHCID 101052081-Methyl-8-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepineHCID 102422038-Chloro-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepine
HCID 10243496
8-Trifluoromethyl-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepine
HCID 102638397,8-Dichloro-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepine
HCID 103318418-Bromo-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine
HCID 103801018-Iodo-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepine
HCID 10467471HCID 10467471, compound
HCID 117787918-Iodo-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Product 1

HCID 104652638-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine

Procedure

8Bromo-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 8-Iodo-1methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 8-Trifluoromethyl-1-methyl-2,3,4,5-tetrahydro-1H-3benzazepine; 8-Trifluoromethyl-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 8Chloro-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 8-Bromo-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 8-Iodo-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 7,8-Dichloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 7,8-Dichloro-1-ethyl-2,3,4,5tetrahydro-1H-3-benzazepine; 8-Chloro-7-fluoro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; and 8-Chloro-7-fluoro-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepine; or a pharmaceutically acceptable salt, solvate or hydrate thereof.

Sources & evidence

ORD record
ord-a933917cdaf94e6a93144403fa5cbd45
Source dataset
uspto-grants-2013_11
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08575149B2

Reaction notes

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