Water → 2-Hydroxy-4-phenylthiazole
Reaction equation
[C:1]1([C:7](=O)[CH2:8][S:9][C:10]#[N:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH:13]S(O)(=O)=O.O>CC(O)=O>[C:1]1([C:7]2[NH:11][C:10](=[O:13])[S:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 1-phenyl-2-thiocyanato-ethanone (20 g, 113 mmol) in HOAc (100 mL) was added 50% aqueous H2SO4 (20 mL). The mixture was refluxed for 10 min. The mixture was poured into water. The solid formed was collected by filtration to give crude 4-phenyl-3H-thiazol-2-one (20 g) which was used for the next step without further purification.
Workup
- temperatureThe mixture was refluxed for 10 min
- customThe solid formed
- filtrationwas collected by filtration
Sources & evidence
- ORD record
- ord-24148e6e66124618a3b0215e91a63f63
- Source dataset
- uspto-grants-2013_11
- Patent number
- US08575156B2
Reaction notes
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