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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2040113Generated: October 26, 2026

3-azetidinecarboxylic Acid → 1-{5-[4-(2-Isopropyl-phenoxy)-benzylidene]-4-oxo-4,5-dihydro-thiazol-2-yl}-azetidine-3-carboxylic acid

https://huagongshe.com/reaction/2040113

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-azetidinecarboxylic AcidHCID 93192—
Reactant5-[4-(2-Isopropyl-phenoxy)-benzylidene]-2-methylsulfanyl-thiazol-4-oneHCID 69089929—
SolventDimethylformamideHCID 6228—
Product1-{5-[4-(2-Isopropyl-phenoxy)-benzylidene]-4-oxo-4,5-dihydro-thiazol-2-yl}-azetidine-3-carboxylic acidHCID 69090386—

Reaction Steps

was prepared from 5-[4-(2-Isopropyl-phenoxy)-benzylidene]-2-methylsulfanyl-thiazol-4-one and azetidine-3-carboxylic acid and substituting MeCN with DMF as described in Example 5C

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08580832B2
Source datasetuspto-grants-2013_11
ORD IDord-0a181029bd3b42d4bbd01523928417cf
Source noteuspto-grants-2013_11