1-Ethynyl-2-fluorobenzene → 6-(2-Fluoro-phenylethynyl)-2-methyl-pyrazolo[1,5-a]pyrimidine

Reaction equation

Br[C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([CH3:11])[CH:10]=2)[CH:7]=1.[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[F:20])#[CH:13]>>[F:20][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[C:12]#[C:13][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([CH3:11])[CH:10]=2)[CH:7]=1

Participants

Reactant 2

HCID 6433581-Ethynyl-2-fluorobenzene

HCID 159800416-Bromo-2-methylpyrazolo[1,5-a]pyrimidine

Product 1

HCID 532470736-(2-Fluoro-phenylethynyl)-2-methyl-pyrazolo[1,5-a]pyrimidine

Procedure

The title compound, light yellow solid, MS: m/e=252.1 (M+H+), can be prepared in accordance with the general method of example 1 from 6-bromo-2-methylpyrazolo[1,5-a]pyrimidine and 1-ethynyl-2-fluoro-benzene.

Sources & evidence

ORD record: ord-4b5cb2f668994591a5c3464912f6f2b9
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08586581B2

Reaction notes

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