Nitric Acid → HCID 86669290, compound
Reaction equation
[N+:1]([O-:4])(O)=[O:2].[CH3:5][O:6][C:7](=[O:20])[C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[N:10][C:9]=1[O:15][CH2:16][CH:17]([F:19])[F:18]>OS(O)(=O)=O>[CH3:5][O:6][C:7](=[O:20])[C:8]1[CH:13]=[C:12]([N+:1]([O-:4])=[O:2])[C:11]([Cl:14])=[N:10][C:9]=1[O:15][CH2:16][CH:17]([F:19])[F:18]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Fuming HNO3 (25 mL) is added at rt to 6-chloro-2-(2,2-difluoro-ethoxy)-nicotinic acid methyl ester (10.7 g, 42.5 mmol) in concentrated H2SO4 (50 mL) and stirred for 10 min. The reaction mixture is added dropwise to ice water, stirred and filtered. The filtercake is washed with water and dried at 50° C.
Workup
- stirringstirred
- filtrationfiltered
- washThe filtercake is washed with water
- customdried at 50° C.
Sources & evidence
- ORD record
- ord-af8a17d0cedc4e7d932596a1f7c8ade4
- Source dataset
- uspto-grants-2013_11
- Patent number
- US08586604B2
Reaction notes
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