Sodium Hydroxide → HCID 86669311, compound

Reaction equation

C[O:2][C:3](=[O:19])[C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[C:7]([NH2:13])=[N:6][C:5]=1[O:14][CH2:15][CH:16]([F:18])[F:17].[OH-].[Na+]>>[F:18][CH:16]([F:17])[CH2:15][O:14][C:5]1[N:6]=[C:7]([NH2:13])[C:8]([N+:10]([O-:12])=[O:11])=[CH:9][C:4]=1[C:3]([OH:19])=[O:2]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 86664895HCID 86664895, compound

Product 1

HCID 86669311HCID 86669311, compound

Procedure

The sub-title compound is prepared from 2-(2,2-difluoro-ethoxy)-6-amino-5-nitro-nicotinic acid methyl ester (1.3 g, 4.8 mmol) and 1 M NaOH in analogy to example 1e. Yield: 0.88 g (70%).

Sources & evidence

ORD record: ord-f38fd1f37b6542c2905509f6f3179e53
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08586604B2

Reaction notes

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