Sodium Hydroxide → HCID 86669315, compound
Reaction equation
[Cl:1][C:2]1[C:15]([NH:16][C:17]2[NH:18][C:19]3[C:20]([N:34]=2)=[N:21][C:22]([O:29][CH2:30][CH:31]([F:33])[F:32])=[C:23]([C:25]([O:27]C)=[O:26])[CH:24]=3)=[C:14]([Cl:35])[CH:13]=[CH:12][C:3]=1[CH2:4][NH:5][C:6](=[O:11])[C:7]([CH3:10])([CH3:9])[CH3:8].[OH-].[Na+]>CO>[Cl:1][C:2]1[C:15]([NH:16][C:17]2[NH:18][C:19]3[C:20]([N:34]=2)=[N:21][C:22]([O:29][CH2:30][CH:31]([F:32])[F:33])=[C:23]([C:25]([OH:27])=[O:26])[CH:24]=3)=[C:14]([Cl:35])[CH:13]=[CH:12][C:3]=1[CH2:4][NH:5][C:6](=[O:11])[C:7]([CH3:10])([CH3:9])[CH3:8]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of N-{2,4-dichloro-3-[6-methoxycarbonyl-5-(2,2-difluoro-ethoxy)-1H-imidazo[4,5-b]pyridin-2-ylamino]-benzyl)-2,2-dimethyl-propionamide (9.80 g, 12.0 mmol) and 1 N NaOH (40 ml) in MeOH (40 ml) is stirred overnight at rt and 45 min at reflux. Then the mixture is concentrated, acidified with 1 N aq. HCl-solution and the precipitate is filtered, dried and purified by HPLC.