Phosphine oxide, (chloromethyl)dimethyl- → HCID 19689193, compound

HRID 2046

Reaction equation

HRID 2046 reaction equation
[Na].[Br:2][C:3]1[N:11]([CH3:12])[C:10]2[C:9](=[O:13])[NH:8][C:7](=[O:14])[N:6]([CH3:15])[C:5]=2[N:4]=1.Cl[CH2:17][P:18](=[O:21])([CH3:20])[CH3:19]>>[Br:2][C:3]1[N:11]([CH3:12])[C:10]2[C:9](=[O:13])[N:8]([CH2:17][P:18](=[O:21])([CH3:20])[CH3:19])[C:7](=[O:14])[N:6]([CH3:15])[C:5]=2[N:4]=1

Participants

3

Reactant 2

HCID 74224Phosphine oxide, (chloromethyl)dimethyl-HCID 67653895HCID 67653895, compound

Product 1

HCID 19689193HCID 19689193, compound

Procedure

The title substance was prepared from 28 g (0.1 mol) of 8-bromo-3,7-dimethylxanthine sodium salt and chloromethyldimethylphosphine oxide analogously to Example 59 and chromatographed on silica gel.

Workup

  1. customchromatographed on silica gel

Sources & evidence

ORD record
ord-ce9a106c829041ce87d64ebe4577218f
Source dataset
uspto-grants-1998_03
Patent number
US05728686

Linked notes

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