6-Chloro-5-methylpyridazin-3(2H)-one → 6-Chloro-2,5-dimethylpyridazin-3(2H)-one

Reaction equation

[Cl:1][C:2]1[C:3]([CH3:9])=[CH:4][C:5](=[O:8])[NH:6][N:7]=1.Cl[C:11]1C=C(C)C(=O)N(C)N=1>>[Cl:1][C:2]1[C:3]([CH3:9])=[CH:4][C:5](=[O:8])[N:6]([CH3:11])[N:7]=1

Participants

Reactant 2

HCID 1648716-Chloro-5-methylpyridazin-3(2H)-one

HCID 598459736-Chloro-2,4-dimethylpyridazin-3(2H)-one

Product 1

HCID 581093296-Chloro-2,5-dimethylpyridazin-3(2H)-one

Procedure

The title intermediate was prepared from 6-chloro-5-methyl-2H-pyridazin-3-one following a procedure analogous to that described for intermediate 6-chloro-2,4-dimethyl-2H-pyridazin-3-one in Example 17*. Mass spectrum (ESI+): m/z=159/161 (CI) [M+H]+

Sources & evidence

ORD record: ord-521ffdada4f74c0aaf007dd78fa67cfb
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08592410B2

Reaction notes

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