Isopropanol hydrochloride → 1218764-02-3

Reaction equation

[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[C:5]([N:13](C)[C:14](=O)OC(C)(C)C)[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[ClH:24].CC(O)C>>[ClH:24].[CH3:14][NH:13][C:5]1[CH:6]=[C:7]([C:9]([F:10])([F:11])[F:12])[CH:8]=[C:3]([C:2]([F:1])([F:22])[F:23])[CH:4]=1

Participants

Reactant 2

HCID 21912024Isopropanol hydrochloride

HCID 86655660HCID 86655660, compound

Product 1

HCID 866556611218764-02-3Yield 93%

Conditions

Temperature: 50 °C

Procedure

To the compound (12.4 g) obtained in step 2 was added 2N hydrogen chloride/2-propanol (100 mL), and the mixture was stirred at 50° C. for 2 hr. The reaction mixture was concentrated under reduced pressure to give the title compound (9.36 g, 93%) as a white powder.

Workup

concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record: ord-00db87f2bb534e219705fd03a03b16a4
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08592454B2

Reaction notes

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