Ammonia → Ethyl 4-amino-7-fluoroquinoline-3-carboxylate
Reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([F:12])=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[C:13]([O:15][CH2:16][CH3:17])=[O:14].[NH3:18]>>[CH2:16]([O:15][C:13]([C:3]1[CH:4]=[N:5][C:6]2[C:11]([C:2]=1[NH2:18])=[CH:10][CH:9]=[C:8]([F:12])[CH:7]=2)=[O:14])[CH3:17]Participants
3
Procedure
Prepared as in Example 1a from ethyl 4-chloro-7-fluoroquinoline-3-carboxylate (Example 9b) and ammonia as an off white solid (99%). MS 235 (MH+).
Sources & evidence
- ORD record
- ord-d6cc0e0d299f4ff2ba58e3ba781cf253
- Source dataset
- uspto-grants-2013_11
- Patent number
- US08592592B2
Reaction notes
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