Acetylacetone → Ethanone, 1-(4-amino-2-methyl-5-(2-methylphenyl)-1H-pyrrol-3-yl)-
Reaction equation
[NH2:1][CH:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH3:11])[C:3]#[N:4].[C:12]([CH2:15][C:16](=O)[CH3:17])(=[O:14])[CH3:13]>CO>[C:12]([C:15]1[C:3]([NH2:4])=[C:2]([C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[CH3:11])[NH:1][C:16]=1[CH3:17])(=[O:14])[CH3:13]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Starting from 2-amino-2-(o-tolyl)acetonitrile and acetylacetone, the open-chain intermediate compound is obtained, b.p. 120° C./0.2 mm Hg. The title compound is obtained in a 77% overall yield, m.p. 258° C. (from methanol).
Workup
- customthe open-chain intermediate compound is obtained
Sources & evidence
- ORD record
- ord-eaf603995a9a46eca688fb76b6c95cf7
- Source dataset
- uspto-grants-1980_04
- Patent number
- US04198502
Reaction notes
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