Methyl iodide → HCID 178503857, compound
Reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[NH:7][C:8]([NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[S:9].[CH3:17][I:18]>CO>[IH:18].[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[NH:7][C:8]([S:9][CH3:17])=[N:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 3.0 g (0.013 mole) of N-(1-methylimidazol-2-yl)-N'-phenylthiourea in 50 ml of methanol is added 2.13 g (0.015 mole) of methyl iodide. The solution is heated under reflux for 2 hr, the solvent is evaporated and the residue is recrystallized from acetone-ether to give methyl N-(1-methylimidazol-2-yl)-N'-phenylcarbamimidothioate hydroiodide; m.p. 115°-118° C.
Workup
- temperatureThe solution is heated
- temperatureunder reflux for 2 hr
- customthe solvent is evaporated
- customthe residue is recrystallized from acetone-ether
Sources & evidence
- ORD record
- ord-400c710788dd4492a1beb4781e19078d
- Source dataset
- uspto-grants-1980_01
- Patent number
- US04182865
Reaction notes
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