Ammonia → 4-butoxybenzamide
Reaction equation
[CH2:1]([O:5][C:6]1[CH:14]=[CH:13][C:9]([C:10](Cl)=[O:11])=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH3:4].[NH3:15]>C(Cl)(Cl)Cl>[CH2:1]([O:5][C:6]1[CH:14]=[CH:13][C:9]([C:10]([NH2:15])=[O:11])=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH3:4]Participants
4
Reagents, catalysts & solvents 1
Procedure
Chilled to 20°, a solution of 84 g (0.39 mole) of a solution of 4-n-butoxybenzoyl chloride in 700 ml of AR chloroform, then saturated with anhydrous ammonia. The mixture was stirred for 20 min. to 0°, then the white precipitate collected, washed with cold water and oven-dried to 60° to give 76 g, m.p. shrinks 160°, melts 162°-164°.
Workup
- temperatureChilled to 20°
- customthe white precipitate collected
- washwashed with cold water
- customoven-dried to 60°
- customto give 76 g
- customshrinks 160°
- custommelts 162°-164°
Sources & evidence
- ORD record
- ord-1506df6ddfcf4c86b4c1a0c86eccd7f3
- Source dataset
- uspto-grants-1980_01
- Patent number
- US04182881
Reaction notes
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