1-Methyl-4-piperidone → 1,2,7,8,9,10-Hexahydro-8-methylpyrido[3',4':4,5]pyrrolo[1,2,3-de][1,4]benzoxazine hydrochloride

Reaction equation

[ClH:1].N[N:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[O:6][CH2:5][CH2:4]1.[CH3:13][N:14]1[CH2:19][CH2:18][C:17](=O)[CH2:16][CH2:15]1>>[ClH:1].[CH3:13][N:14]1[CH2:19][CH2:18][C:17]2[N:3]3[C:8]4[C:9](=[CH:10][CH:11]=[CH:12][C:7]=4[O:6][CH2:5][CH2:4]3)[C:16]=2[CH2:15]1

Participants

Reactant 2

HCID 740491-Methyl-4-piperidone

HCID 224889852H-benzo[b][1,4]oxazin-4(3H)-amine hydrochloride

Product 1

HCID 203047381,2,7,8,9,10-Hexahydro-8-methylpyrido[3',4':4,5]pyrrolo[1,2,3-de][1,4]benzoxazine hydrochloride

Procedure

By a procedure similar to Example 110, 4-amino-3,4-dihydro-2H-1,4-benzoxazine hydrochloride is reacted with 1-methyl-4-piperidone to yield the title compound, m.p. 245°-246°.

Sources & evidence

ORD record: ord-a7f8ba69c0a742c880f6229e1f1e71a8
Source dataset: uspto-grants-1980_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04183936

Reaction notes

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