3-Aminocinnamic acid ethyl ester → 3-(3-[(4,4'-Difluoro-biphenyl-3-carbonyl)-amino]-phenyl)-acrylic Acid Ethyl Ester
Reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)=[CH:4][C:3]=1[C:15]([OH:17])=O.[CH2:18]([O:20][C:21](=[O:31])[CH:22]=[CH:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([NH2:30])[CH:25]=1)[CH3:19]>>[CH2:18]([O:20][C:21](=[O:31])[CH:22]=[CH:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([NH:30][C:15]([C:3]2[CH:4]=[C:5]([C:8]3[CH:9]=[CH:10][C:11]([F:14])=[CH:12][CH:13]=3)[CH:6]=[CH:7][C:2]=2[F:1])=[O:17])[CH:25]=1)[CH3:19]Participants
3
Procedure
4,4′-Difluoro-biphenyl-3-carboxylic acid (100 mg, 0.43 mmol) was coupled to aniline (60)(82 mg, 0.43 mmol) using Method C to give the title compound.
Sources & evidence
- ORD record
- ord-5e79b046ec1c43dc806a2d562a2dec6f
- Source dataset
- uspto-grants-2008_02