4-Fluorobenzene-1,2-diamine → HCID 10041790, compound

Reaction equation

[NH2:1][C:2]1[N:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[CH:6][C:3]=1[CH:4]=O.[F:17][C:18]1[CH:23]=[CH:22][C:21]([NH2:24])=[C:20]([NH2:25])[CH:19]=1>>[F:17][C:18]1[CH:23]=[CH:22][C:21]2[N:24]=[C:4]([C:3]3[C:2]([NH2:1])=[N:9][CH:8]=[C:7]([C:10]4[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=4)[CH:6]=3)[NH:25][C:20]=2[CH:19]=1

Participants

Reactant 2

HCID 1645844-Fluorobenzene-1,2-diamine

HCID 58668625HCID 58668625, compound

Product 1

HCID 10041790HCID 10041790, compound

Procedure

Using the procedure of step (b) in Example 15, utilizing 2-amino-5-(4-fluorophenyl)nicotinaldehyde and 4-fluoro-o-phenylenediamine gave 3-(6-fluoro-1H-benzimidazol-2-yl)-5-(4-fluorophenyl)-pyridin-2-amine.

Sources & evidence

ORD record: ord-f48c04091bbd4e408f9a899afdf43bda
Source dataset: uspto-grants-2008_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07329678B2

Reaction notes

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