HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 20545Generated: October 26, 2026
Hydrochloric Acid → 3-chloro-4-fluoro-N,N-dimethylbenzenesulfonamide
https://huagongshe.com/reaction/20545
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3-Chloro-4-fluorobenzenesulphonyl chloride | HCID 145222 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-chloro-4-fluoro-N,N-dimethylbenzenesulfonamide | HCID 697776 | 94% |
Reaction Steps
A solution of 2M dimethylamine in THF (5.9 mL, 12 mmol) was diluted with DCM (25 mL) and cooled to 0° C. DIPEA (2.8 mL) was added, followed by and 3-chloro-4-fluorobenzenesulfonyl chloride (2.5 g, 11 mmol) in DCM (25 mL). The resulting mixture was allowed to warm to rt and stirred for 3 hours. Water (5 mL) and 1M hydrochloric acid (16 mL) was added. The organic phase was separated and evaporated under reduced pressure to afford the title compound (2.4 g, 94%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07745475B2 |
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| Source dataset | uspto-grants-2010_06 |
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| ORD ID | ord-089cb75a2f9c488fb48bf383b14768cf |
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| Source note | uspto-grants-2010_06 |
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