Sodium Hydroxide → 5-Fluoro-2,4-dinitrophenol
Reaction equation
[F:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([N+:11]([O-:13])=[O:12])=[C:4](F)[CH:3]=1.[OH-:15].[Na+]>O>[F:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([N+:11]([O-:13])=[O:12])=[C:4]([OH:15])[CH:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
0.41 g of 1,3-difluoro-4,6-dinitrobenzene was dissolved in 8 ml of 0.5 N aqueous sodium hydroxide solution and refluxed for 2 hours. After cooling, it was diluted with water and extracted three times with diethyl ether. The aqueous phase was made acidic by adding 1N hydrochloric acid and extracted with diethyl ether. The organic phase was dried on sodium sulfate and concentrated by evaporation in a vacuum.
Workup
- temperaturerefluxed for 2 hours
- temperatureAfter cooling
- extractionextracted three times with diethyl ether
- additionby adding 1N hydrochloric acid
- extractionextracted with diethyl ether
- customThe organic phase was dried on sodium sulfate
- concentrationconcentrated by evaporation in a vacuum
Sources & evidence
- ORD record
- ord-c6537bed28614d2da777b036950746fd
- Source dataset
- uspto-grants-2008_02
- Patent number
- US07329679B2
Reaction notes
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