Formamide → HCID 135553012, compound
Reaction equation
[NH2:1][C:2]1[C:10]([Br:11])=[CH:9][C:8]([Cl:12])=[CH:7][C:3]=1[C:4](O)=[O:5].[CH:13]([NH2:15])=O>>[Br:11][C:10]1[CH:9]=[C:8]([Cl:12])[CH:7]=[C:3]2[C:2]=1[N:1]=[CH:13][NH:15][C:4]2=[O:5]Participants
3
Procedure
8-Bromo-6-chloro-4(3H) quinazolinone was prepared from 2-amino-3-bromo-5-chlorobenzoic acid (10 g, 40 mmol). The acid was heated in excess formamide (50 mL) at reflux overnight. The mixture was cooled and quenched with water. The solid that formed was washed with acetonitrile, 6.7 g crude (65%); MS: 260.8 (M+H)+
Workup
- temperatureat reflux overnight
- temperatureThe mixture was cooled
- customquenched with water
- customThe solid that formed
- washwas washed with acetonitrile, 6.7 g crude (65%)
Sources & evidence
- ORD record
- ord-4dd82de2a8234fc5b58672625743b906
- Source dataset
- uspto-grants-2008_02
- Patent number
- US07332506B2
Reaction notes
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