Acetic Anhydride → N-(5-Chloro-2-methoxyphenyl)acetamide
Reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[O:9][CH3:10].[C:11](OC(=O)C)(=[O:13])[CH3:12]>[Zn]>[C:11]([NH:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[O:9][CH3:10])(=[O:13])[CH3:12]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
0.2 mol (31.5 g) of 2-amino-4-chloroanisole, 40 ml of absolute alcohol, 20 ml of acetic anhydride and a pinch of zinc powder are placed in a 150 ml flask; the solution is brought to reflux for 30 minutes. The reaction liquid is poured onto crushed ice. The product obtained is separated; it is crystallized in a methanol/water mixture (20/80).
Workup
- temperatureto reflux for 30 minutes
- customThe reaction liquid
- additionis poured
- customonto crushed ice
- customThe product obtained
- customis separated
- customit is crystallized in a methanol/water mixture (20/80)
Sources & evidence
- ORD record
- ord-c42d966b02af44adb9dfab5d9b71aeeb
- Source dataset
- uspto-grants-1980_07
- Patent number
- US04211776
Reaction notes
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