4,4,6-Trimethylhexahydropyrimidine → 4,4,6-Trimethyl-3,4,5,6-tetrahydropyrimidine

HRID 2057740Notes

Reaction equation

HRID 2057740 reaction equation
[CH3:1][C:2]1([CH3:9])[CH2:7][CH:6]([CH3:8])[NH:5][CH2:4][NH:3]1>[Co]=O>[CH3:1][C:2]1([CH3:9])[CH2:7][CH:6]([CH3:8])[N:5]=[CH:4][NH:3]1

Participants

3

Reactant 1

HCID 202254024,4,6-Trimethylhexahydropyrimidine

Product 1

HCID 203301244,4,6-Trimethyl-3,4,5,6-tetrahydropyrimidineYield 10%

Reagents, catalysts & solvents 1

HCID 14786Cobalt(II) oxideCatalyst

Procedure

Heating a mixture of 12.6 g. of 4,4,6-trimethyl hexahydropyrimidine and 0.5 g. of cobalt oxide on kieselguhr for 9 hrs. at 185°-190° C. yielded 10% of 4,4,6-trimethyl-3,4,5,6,-tetrahydropyrimidine.

Workup

  1. temperatureHeating
  2. additiona mixture of 12.6 g

Sources & evidence

ORD record
ord-5ddfa6897ddd4349953f05981fcf3330
Source dataset
uspto-grants-1980_07
Patent number
US04212843

Reaction notes

Loading…