Potassium Permanganate → 5-Butyryl-6-methoxy-1-methyl-benzimidazole-2-carboxylic acid
Reaction equation
[C:1]([C:6]1[C:17]([O:18][CH3:19])=[CH:16][C:9]2[N:10]([CH3:15])[C:11]([CH2:13][OH:14])=[N:12][C:8]=2[CH:7]=1)(=[O:5])[CH2:2][CH2:3][CH3:4].[Mn]([O-])(=O)(=O)=[O:21].[K+]>>[C:1]([C:6]1[C:17]([O:18][CH3:19])=[CH:16][C:9]2[N:10]([CH3:15])[C:11]([C:13]([OH:21])=[O:14])=[N:12][C:8]=2[CH:7]=1)(=[O:5])[CH2:2][CH2:3][CH3:4]Participants
3
Procedure
In a manner analogous to that described in Example 12, 5.2 g of 5-butyryl-6-methoxy-1-methyl-benzimidazole-2-methanol are oxidised with 4.5 g of potassium permanganate to give 5-butyryl-6-methoxy-1-methyl-benzimidazole-2-carboxylic acid with a melting point above 85° (decomposition)
Sources & evidence
- ORD record
- ord-7ff9a5e9ea444aa8be8e3bb0e8883874
- Source dataset
- uspto-grants-1980_07