Acetic Acid → Diethyl (4-formylphenyl)phosphonate

Reaction equation

[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([P:8]([O:13][CH2:14][CH3:15])(=[O:12])[O:9][CH2:10][CH3:11])=[CH:4][CH:3]=1.C1N2CN3CN(C2)CN1C3.C(O)(=[O:28])C>>[CH:1]([C:2]1[CH:3]=[CH:4][C:5]([P:8]([O:13][CH2:14][CH3:15])(=[O:12])[O:9][CH2:10][CH3:11])=[CH:6][CH:7]=1)=[O:28]

Participants

Reactant 3

HCID 176Acetic Acid

HCID 4101Hexamethylenetetramine

HCID 108680441-Diethoxyphosphoryl-4-methylbenzene

Product 1

HCID 2773714Diethyl (4-formylphenyl)phosphonate

Procedure

Diethyl 4-formyl-benzenephosphonate was prepared in a known manner by bromination of diethyl 4-methyl-benzenephosphonate and subsequent reaction of the product with hexamethylenetetramine in acetic acid.

Sources & evidence

ORD record: ord-13582387ebca4ba188f9315261098321
Source dataset: uspto-grants-1982_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04317782

Reaction notes

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