Sulfuric Acid → 1,3-dimethyl-4-nitro-1H-pyrazole-5-carboxamide

HRID 2058610

Reaction equation

HRID 2058610 reaction equation
[CH3:1][N:2]1[C:6]([C:7]#[N:8])=[C:5]([N+:9]([O-:11])=[O:10])[C:4]([CH3:12])=[N:3]1.S(=O)(=O)(O)[OH:14]>O>[CH3:1][N:2]1[C:6]([C:7]([NH2:8])=[O:14])=[C:5]([N+:9]([O-:11])=[O:10])[C:4]([CH3:12])=[N:3]1

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 965071,3-dimethyl-4-nitro-1H-pyrazole-5-carbonitrile

Product 1

HCID 12297641,3-dimethyl-4-nitro-1H-pyrazole-5-carboxamide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

27.2 g of 1,3-dimethyl-4-nitropyrazole-5-carbonitrile and 65 ml of concentrated sulfuric acid are stirred at 80° C. for 6 hours. The mixture is poured into 700 g of ice and water, and the precipitate is filtered off and suspended in ice-water; the suspension is neutralized with sodium bicarbonate to yield 27.3 g of 1,3-dimethyl-4-nitropyrazole-5-carboxamide, mp 164° to 165° C.

Workup

  1. filtrationthe precipitate is filtered off

Sources & evidence

ORD record
ord-58589026adbf4087aa1210eba6aabe36
Source dataset
uspto-grants-1982_03
Patent number
US04317823

Linked notes

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