Sodium Hydroxide → Bupivacaine (USAN:INN:BAN)

HRID 2059964

Reaction equation

HRID 2059964 reaction equation
[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[CH:10]([C:11]([NH:13][C:14]2[C:15]([CH3:21])=[CH:16][CH:17]=[CH:18][C:19]=2[CH3:20])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6]1.Cl.[OH-].[Na+]>O>[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[CH:10]([C:11]([NH:13][C:14]2[C:15]([CH3:21])=[CH:16][CH:17]=[CH:18][C:19]=2[CH3:20])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 64737Bupivacaine Hydrochloride

Product 1

HCID 2474Bupivacaine (USAN:INN:BAN)

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Bupivacaine hydrochloride (Sigma-Aldrich Corporation, St. Louis, Mo.) was dissolved in de-ionized (DI) water at a concentration of 40 mg/ml (saturation). A calculated amount of sodium hydroxide (1 N solution) was added to the solution and the pH of the final mixtures was adjusted to 10 to precipitate the BP bate. The precipitated product was filtered, and further washed with DI water for at least three times. The precipitated product was dried at approximately 40° C. in vacuum for 24 h.

Workup

  1. customto precipitate the BP bate
  2. filtrationThe precipitated product was filtered
  3. washfurther washed with DI water for at least three times
  4. customThe precipitated product was dried at approximately 40° C. in vacuum for 24 h.

Sources & evidence

ORD record
ord-bbe0ae0487d0453db13663838e0d921d
Source dataset
uspto-grants-2012_10
Patent number
US08278330B2

Linked notes

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