HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bms-973013 → 1-[6'-(5-Fluoro-2,3-dihydro-indole-1-carbonyl)-2'-methoxy-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-4-yl]-1,3-dihydro-imidazo[4,5-b]pyridin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bms-973013 | HCID 22293182 | — |
| Reactant | (4-Chloro-6-methoxy-pyridin-2-yl)-(5-fluoro-2,3-dihydro-indol-1-yl)-methanone | HCID 58386681 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 1-[6'-(5-Fluoro-2,3-dihydro-indole-1-carbonyl)-2'-methoxy-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-4-yl]-1,3-dihydro-imidazo[4,5-b]pyridin-2-one | HCID 58386552 | — |
Reaction Steps
436 mg (2.00 mmol) 1-Piperidin-4-yl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one and 200 mg (0.652 mmol) of (4-chloro-6-methoxy-pyridin-2-yl)-(5-fluoro-2,3-dihydro-indol-1-yl)-methanone in 2 mL NMP were stirred overnight at 120° C. The reaction mixture was purified by preparative HPLC. The product-containing fractions were combined and evaporated down using the rotary evaporator.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278336B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-1ed47c91d9714f61b2d3f3551fcc692d |
| Source note | uspto-grants-2012_10 |