4-Fluorophenylboronic acid → 6-(4-Fluorophenyl)pyridin-3-OL

Reaction equation

Br[C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][N:3]=1.[F:9][C:10]1[CH:15]=[CH:14][C:13](B(O)O)=[CH:12][CH:11]=1>>[F:9][C:10]1[CH:15]=[CH:14][C:13]([C:2]2[N:3]=[CH:4][C:5]([OH:8])=[CH:6][CH:7]=2)=[CH:12][CH:11]=1

Participants

Reactant 2

HCID 2856454-Fluorophenylboronic acid

HCID 27628652-Bromo-5-hydroxypyridine

Product 1

HCID 463127886-(4-Fluorophenyl)pyridin-3-OLYield 51%

Procedure

The title compound was prepared according to the method described for Preparation 17 using 2-bromo-5-hydroxypyridine and 4-fluorophenylboronic acid to afford the title compound as an off-white solid (270 mg, 51%)

Workup

customThe title compound was prepared

Sources & evidence

ORD record: ord-79d791ec564f4382b84e1f97d5c97442
Source dataset: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08278343B2

Reaction notes

Loading…