4-Chlorophenylboronic acid → 6-(4-Chlorophenyl)pyridin-3-ol

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5](B(O)O)=[CH:4][CH:3]=1.Br[C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][N:13]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:12]2[N:13]=[CH:14][C:15]([OH:18])=[CH:16][CH:17]=2)=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 742994-Chlorophenylboronic acid

HCID 27628652-Bromo-5-hydroxypyridine

Product 1

HCID 532292686-(4-Chlorophenyl)pyridin-3-olYield 73%

Procedure

The title compound was prepared according to the method described for Preparation 17 using 4-chlorophenylboronic acid and 2-bromo-5-hydroxypyridine to afford the title compound as an off-white solid (1.3 g, 73%)

Workup

customThe title compound was prepared

Sources & evidence

ORD record: ord-5bc14d068d9840bba49b8f6957b6f256
Source dataset: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08278343B2

Reaction notes

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