HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isoflurane → Desflurane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isoflurane | HCID 3763 | — |
| Reactant | Hydrofluoric Acid | HCID 14917 | — |
| Reactant | Desflurane | HCID 42113 | — |
| Catalyst | Chromia | HCID 517277 | — |
| Product | Desflurane | HCID 42113 | — |
| Product | Desflurane Hydrogen Fluoride | HCID 86625408 | — |
Reaction Steps
It has been found that fractional distillation of a crude reaction mixture obtained in the manufacture of desflurane, for example, by reacting hydrogen fluoride with isoflurane over a bed of chromia catalyst, results in the removal of desflurane in the form of a desflurane/hydrogen fluoride azeotrope that boils below the boiling point of hydrogen fluoride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08283500B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-b089b2ff411140a2a8ecf40828639600 |
| Source note | uspto-grants-2012_10 |