Ammonia → 6-Amino-3-methoxy-2-pyrazinecarboxamide
Reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8](OC)=[O:9])[C:5]([O:12][CH3:13])=[N:4][CH:3]=1.[NH3:14]>CO>[NH2:1][C:2]1[N:7]=[C:6]([C:8]([NH2:14])=[O:9])[C:5]([O:12][CH3:13])=[N:4][CH:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
In 70 mL of methanol is dissolved 3.50 g of methyl 6-amino-3-methoxy-2-pyrazinecarboxylate. Gaseous ammonia is introduced to saturate the solution with ammonia. The solution is stirred at ambient temperature for 14 hours. The solvent is distilled off from the reaction mixture under reduced pressure to obtain 3.1 g of 6-amino-3-methoxy-2-pyrazinecarboxamide.
Workup
- concentrationto saturate the solution with ammonia
- distillationThe solvent is distilled off from the reaction mixture under reduced pressure
Sources & evidence
- ORD record
- ord-d6253dc31ef84896a1e16e8c6a29b2af
- Source dataset
- uspto-grants-2012_10
- Patent number
- USRE043748E1
Reaction notes
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