p-Methylpropiophenone → N-(2-Methyl-6-phenyl-pyrimidin-4-yl)-N'-[1-p-tolyl-propylidene]-hydrazine

HRID 2063616

Reaction equation

HRID 2063616 reaction equation
[NH:1]([C:3]1[CH:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:6]=[C:5]([CH3:15])[N:4]=1)[NH2:2].[C:16]1([CH3:26])[CH:21]=[CH:20][C:19]([C:22](=O)[CH2:23][CH3:24])=[CH:18][CH:17]=1>C(O)C>[CH3:15][C:5]1[N:4]=[C:3]([NH:1][N:2]=[C:22]([C:19]2[CH:20]=[CH:21][C:16]([CH3:26])=[CH:17][CH:18]=2)[CH2:23][CH3:24])[CH:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:6]=1

Participants

4

Reactant 2

HCID 21429p-MethylpropiophenoneHCID 8246274-Hydrazinyl-2-methyl-6-phenylpyrimidine

Product 1

HCID 73320072N-(2-Methyl-6-phenyl-pyrimidin-4-yl)-N'-[1-p-tolyl-propylidene]-hydrazine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared from 4-hydrazino-2-methyl-6-phenylpyrimidine (300 mg, 1.5 mmol) and 1-p-Tolyl-propan-1-one (174 μL, 1.05 mmol) in 3.0 mL of ethanol by a procedure similar to example 1, step 4 yielding 110 mg (22%) of a white solid. HPLC Purity: 96%.

Sources & evidence

ORD record
ord-a4909e30ae9c4eb38b3b8ef8437c01bc
Source dataset
uspto-grants-2012_10
Patent number
US08288398B2

Linked notes

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