4'-Methoxyacetophenone → N-[1-(4-Methoxy-phenyl)-ethylidene]-N'-(2-methyl-6-phenyl-pyrimidin-4-yl)-hydrazine

HRID 2063618

Reaction equation

HRID 2063618 reaction equation
[NH:1]([C:3]1[CH:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:6]=[C:5]([CH3:15])[N:4]=1)[NH2:2].[CH3:16][O:17][C:18]1[CH:23]=[CH:22][C:21]([C:24](=O)[CH3:25])=[CH:20][CH:19]=1>C(O)C>[CH3:16][O:17][C:18]1[CH:23]=[CH:22][C:21]([C:24](=[N:2][NH:1][C:3]2[CH:8]=[C:7]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=3)[N:6]=[C:5]([CH3:15])[N:4]=2)[CH3:25])=[CH:20][CH:19]=1

Participants

4

Reactant 2

HCID 74764'-MethoxyacetophenoneHCID 8246274-Hydrazinyl-2-methyl-6-phenylpyrimidine

Product 1

HCID 73320074N-[1-(4-Methoxy-phenyl)-ethylidene]-N'-(2-methyl-6-phenyl-pyrimidin-4-yl)-hydrazine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared from 4-hydrazino-2-methyl-6-phenylpyrimidine (200 mg, 1.0 mmol) and 1-(4-methoxy-phenyl)-ethanone (150 mg, 1.0 mmol) in 10 mL of ethanol by a procedure similar to example 1, step 4 yielding 35 mg (11%) of a cream solid. HPLC Purity: 98%.

Sources & evidence

ORD record
ord-7dc9bf7074aa40309384111c15ba47af
Source dataset
uspto-grants-2012_10
Patent number
US08288398B2

Linked notes

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