Ethanol → HCID 178494754, compound

To a solution of phosphoric acid mono-(1-{4-[(S)-5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2,6-difluorophenyl}-4-methoxymethyl-piperidin-4-yl)ester (5.0 g, 0.010 mol anhydrous ethanol (50 ml) at 25-30° C., under argon, was added L-arginine (1.76 g, 0.010 mol). The reaction mixture was stirred at 80-85° C. for 0.5 h. Water (5 ml) was added to the reaction mixture and stirring continued further for 1 h at 80-85° C. The reaction mixture was filtered and the filtrate evaporated under reduced pressure. Acetone (25 ml) was added to the residue and triturated. The solvent was decanted. This procedure was repeated twice with acetone (50 ml). Acetone after the third trituration was decanted and the residue dried under reduced pressure to obtain the product as off-white solid, 6.1 g, 91% yield. Aqueous solubility at pH 7 was >200 mg/ml.

1. stirringstirring
2. waitcontinued further for 1 h at 80-85° C
3. filtrationThe reaction mixture was filtered
4. customthe filtrate evaporated under reduced pressure
5. additionAcetone (25 ml) was added to the residue
6. customtriturated
7. customThe solvent was decanted
8. customAcetone after the third trituration was decanted
9. customthe residue dried under reduced pressure

ORD record

ord-bc90fdc944934524955d1636af129569

Source dataset

uspto-grants-2012_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08288416B2