HuagongsheHuagongshe Chemistry Print Report · For research reference only
Selectfluor → 4-amino-8-(cyclopentyloxy)-3-fluoro-7-methoxy-2H-chromen-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Selectfluor | HCID 2724933 | — |
| Reactant | 4-amino-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one | HCID 77174793 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-amino-8-(cyclopentyloxy)-3-fluoro-7-methoxy-2H-chromen-2-one | HCID 86618134 | — |
Reaction Steps
A mixture of 4-amino-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one (100 mg, 0.36 mmol, Example 3, Step 1), Selectfluor (160 mg, 0.45 mmol), and acetonitrile (1.5 mL) were stirred vigorously for 18 h, concentrated, and then purified by silica gel chromatography (7:3→1:4; hexanes:ethyl acetate) to give 4-amino-8-(cyclopentyloxy)-3-fluoro-7-methoxy-2H-chromen-2-one: MS (ESI): 294.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745646B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-1f2b2ae8e5f1496aafb24688b567536b |
| Source note | uspto-grants-2010_06 |