3-Ethyl-4-methoxyaniline → HCID 22478004, compound

Reaction equation

[CH2:1]([C:3]1[CH:4]=[C:5]([NH2:11])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10])[CH3:2].C([C:14]1C=C(CC(N)=O)C=C[C:19]=1[O:20]C)C>>[CH2:1]([C:3]1[CH:4]=[C:5]([NH:11][C:19](=[O:20])[CH3:14])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10])[CH3:2]

Participants

Reactant 2

HCID 220656033-Ethyl-4-methoxyaniline

HCID 82125723HCID 82125723, compound

Product 1

HCID 22478004HCID 22478004, compound

Procedure

By proceeding in a manner similar to Reference Example 33(a) but using 3-ethyl-4-methoxy-phenylamine [2.5 g, Reference Example 30(aa)] there was prepared N-(3-ethyl-4-methoxy-phenyl-acetamide (2.9 g) was prepared as a light brown solid. LC-MS (METHOD K): RT=3.92 minutes, 194.16 (M+H)+.

Workup

customwas prepared as a light brown solid

Sources & evidence

ORD record: ord-b8bc7b41336c4bd08c6b1f7e13c1831a
Source dataset: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08288425B2

Reaction notes

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