Cyclopropanecarbothioamide → HCID 66867565, compound

Reaction equation

[CH3:1][O:2][C:3](=[O:15])[C:4](=O)[CH:5](Cl)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[F:12].[CH:16]1([C:19](=[S:21])[NH2:20])[CH2:18][CH2:17]1>>[CH3:1][O:2][C:3]([C:4]1[N:20]=[C:19]([CH:16]2[CH2:18][CH2:17]2)[S:21][C:5]=1[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[F:12])=[O:15]

Participants

Reactant 2

HCID 22140884Cyclopropanecarbothioamide

HCID 54289762HCID 54289762, compound

Product 1

HCID 66867565HCID 66867565, compound

Procedure

prepared by reaction of 3-chloro-3-(2-fluoro-phenyl)-2-oxo-propionic acid methyl ester with cyclopropanecarbothioic acid amide. LC-MS: tR=1.00 min; [M+H]+=278.3.

Sources & evidence

ORD record: ord-afb000d7a35e4291861a7c1a0be0b36d
Source dataset: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08288435B2

Reaction notes

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