6-fluoro-4H-1,3-benzodioxine-8-carboxylic acid → 6-fluoro-4H-benzo[1,3]dioxine-8-carboxylic acid {(1S,3S,5S)-2-[5-(3-fluoro-phenyl)-2-methyl-thiazole-4-carbonyl]-2-aza-bicyclo[3.1.0]hex-3-ylmethyl}-amide

HRID 2064854Notes

Reaction equation

HRID 2064854 reaction equation
[NH2:1][CH2:2][C@@H:3]1[CH2:8][C@H:7]2[C@H:5]([CH2:6]2)[N:4]1[C:9]([C:11]1[N:12]=[C:13]([CH3:23])[S:14][C:15]=1[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[CH:17]=1)=[O:10].[F:24][C:25]1[CH:26]=[C:27]([C:35](O)=[O:36])[C:28]2[O:33][CH2:32][O:31][CH2:30][C:29]=2[CH:34]=1>>[F:22][C:18]1[CH:17]=[C:16]([C:15]2[S:14][C:13]([CH3:23])=[N:12][C:11]=2[C:9]([N:4]2[C@H:3]([CH2:2][NH:1][C:35]([C:27]3[C:28]4[O:33][CH2:32][O:31][CH2:30][C:29]=4[CH:34]=[C:25]([F:24])[CH:26]=3)=[O:36])[CH2:8][C@H:7]3[C@@H:5]2[CH2:6]3)=[O:10])[CH:21]=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 27799016-fluoro-4H-1,3-benzodioxine-8-carboxylic acidHCID 67081101[(1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hex-2-yl]-[5-(3-fluoro-phenyl)-2-methyl-thiazol-4-yl]-methanone

Product 1

HCID 670812176-fluoro-4H-benzo[1,3]dioxine-8-carboxylic acid {(1S,3S,5S)-2-[5-(3-fluoro-phenyl)-2-methyl-thiazole-4-carbonyl]-2-aza-bicyclo[3.1.0]hex-3-ylmethyl}-amide

Procedure

prepared by reaction of [(1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hex-2-yl]-[5-(3-fluoro-phenyl)-2-methyl-thiazol-4-yl]-methanone with 6-fluoro-4H-benzo[1,3]dioxine-8-carboxylic acid. LC-MS (basic): tR=0.89 min; [M+H]+=512.1.

Sources & evidence

ORD record
ord-b02da52f37a44750b6921a3b59c11101
Source dataset
uspto-grants-2012_10
Patent number
US08288435B2

Reaction notes

Loading…