2-(Trifluoromethyl)cinnamic acid, (E)- → (E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-3-(2-trifluoromethyl-phenyl)-acrylamide

HRID 2065104

Reaction equation

HRID 2065104 reaction equation
[CH3:1][C:2]1([C:7]2[O:11][C:10]([CH2:12][N:13]3[CH:17]=[CH:16][C:15]([NH2:18])=[N:14]3)=[CH:9][CH:8]=2)[O:6]CCO1.[F:19][C:20]([F:33])([F:32])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1/[CH:27]=[CH:28]/[C:29](O)=[O:30]>>[C:2]([C:7]1[O:11][C:10]([CH2:12][N:13]2[CH:17]=[CH:16][C:15]([NH:18][C:29](=[O:30])/[CH:28]=[CH:27]/[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[C:20]([F:32])([F:33])[F:19])=[N:14]2)=[CH:9][CH:8]=1)(=[O:6])[CH3:1]

Participants

3

Reactant 2

HCID 7196252-(Trifluoromethyl)cinnamic acid, (E)-HCID 669287811-[5-(2-Methyl-[1,3]dioxolan-2-yl)-furan-2-ylmethyl]-1H-pyrazol-3-ylamine

Product 1

HCID 42644161(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-3-(2-trifluoromethyl-phenyl)-acrylamide

Procedure

Following general procedure B followed by either C or D, starting from 1-[5-(2-methyl-[1,3]dioxolan-2-yl)-furan-2-ylmethyl]-1H-pyrazol-3-ylamine and (E)-3-(2-trifluoromethyl-phenyl)-acrylic acid.

Sources & evidence

ORD record
ord-df137f4acca547089f4447a96d88f7d9
Source dataset
uspto-grants-2012_10
Patent number
US08288419B2

Linked notes

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