6-Fluorotryptophan, DL- → HCID 45254558, compound
Reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[F:16][C:17]1[CH:18]=[C:19]2[C:29](=[CH:30][CH:31]=1)[C:22]([CH2:23][CH:24]([C:26]([OH:28])=[O:27])[NH2:25])=[CH:21][NH:20]2>>[C:26]([CH:24]([NH:25][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1)[CH2:23][C:22]1[C:29]2[C:19](=[CH:18][C:17]([F:16])=[CH:31][CH:30]=2)[NH:20][CH:21]=1)([OH:28])=[O:27]Participants
3
Procedure
In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with 6-fluoro-DL-tryptophan to provide the title compound in 42% yield as yellow needles (recrystallization from MeOH).
Sources & evidence
- ORD record
- ord-3fd22123d90946b0b9b4a19131c6273e
- Source dataset
- uspto-grants-2012_10